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Product Details
5-HTP is a precursor to serotonin and has replaced tryptophan. 5-HTP is well absorbed after oral administration and has been shown to increase the neurotransmitters, dopamine and norepinephrine; whereas tryptophan does not. This NOW® 5-HTP product offers the benefits of higher potency and a vegetarian formulation extracted from the seed of the African Griffonia simplicifolia plant.
Serotonin (5-HT) is a neurotransmitter synthesized centrally from derivatives of the essential amino acid, tryptophan. 5-hydroxytryptophan (5-HTP) is created in the body via tryptophan hydroxylase, which is subsequently decarboxylated to serotonin (5-HT). 5-HTP is readily absorbed when taken orally and crosses the blood-brain barrier to increase the central nervous system (CNS) synthesis of serotonin. Sleep, appetite, temperature, sexual behaviour, and pain sensation are partially affected by serotonin. Since 5-HTP can increase synthesis of serotonin, 5-HTP is used for several disease states where serotonin is believed to play a significant role including headaches, obesity, mood disorders and numerous other conditions. 5-HTP is one of the few approved natural therapies for fibromyalgia with the possibility of reducing pain severity, morning stiffness, and sleeplessness.
Directions
Adult Dosage:
- Fibromyalgia: Take 1 capsule 3-4 times daily with food. Use for minimum of 2 weeks to see beneficial effects. Consult a health care practitioner for use beyond one year.
- Migraines: Take 1-2 capsules 2-3 times daily with food. Use for a minimum of 2-3 weeks to see beneficial effects. Consult a health care practitioner for use beyond 6 months. To minimize the risk of gastrointestinal side effects, start dosing at 100 mg, 2-3 times per day and slowly increase to effective dose over a 2 week period.
Risk information
Consult a health care practitioner prior to use if you are pregnant or breastfeeding or if you are taking carbidopa or drugs/supplements with serotonergic activity. These may include, but are not limited to, L-tryptophan, S-adenosylmethionine (SAMe), St. John's wort, antidepressants, pain killers, over the counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication. Consult a health care practitioner if symptoms persist or worsen. Discontinue use and consult a health care practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain, or if you experience skin changes. Do not use if you have scleroderma. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Some people may experience diarrhea, nausea, vomiting, abdominal pain and drowsiness.
Ingredients
Each capsule contains :
- L-5-HTP (L-5-Hydroxytryptophan) (Griffonia simplicifolia) (Seed) - 100 mg
Non-Medicinal Ingredients: White Rice Flour, Veg Capsule (hypromellose, water).
Cautions
Consult a health care practitioner if symptoms persist or worsen. Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you are taking carbidopa or drugs/supplements with serotonergic activity. These may include, but are not limited to, L-tryptophan, S-adenosylmethionine (SAMe), St. John's wort, antidepressants, pain killers, over the counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication. Discontinue use and consult a health care practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by serve muscle pain, or if you experience skin changes. Do not use if you have scleroderma. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Some people may experience diarrhea, nausea, vomiting and abdominal pain and drowsiness.
Ingredients
- Hypromellose
- Rice flour
- Water
- L-5-Hydroxytryptophan : 100 mg