Stress is an unavoidable force to which the human organism is constantly exposed in both short-term bursts and over extended periods of time. The body’s ability to withstand the damaging effects of stress is mediated primarily by the adrenal (aka suprarenal) glands: small, triangular glands located on top of the kidneys, that secrete hormones involved in blood-pressure regulation, reproduction, and the stress response. Excessive and prolonged mental and physical stress can lead to adrenal insufficiency and associated symptomatic manifestations including fatigue, immunosuppression, and impaired blood-sugar and blood-pressure control. Adrenal SAP is a combination of vitamins, minerals and adaptogenic herbs that support and strengthen the adrenal glands to improve adrenal function.
Each non‑GMO vegetable capsule contains:
Vitamin C (ascorbic acid) 250 mg
Vitamin B5 (calcium pantothenate) 50 mg
Magnesium (from magnesium bisglycinate) 10 mg
Vitamin B6 (pyridoxal-5'-phosphate) 25 mg
Zinc (from zinc picolinate) 5 mg
Schisandra (Schizandra chinensis) fruit extract, 9% schizandrins 25 mg
Astragalus (Astragalus membranaceus) root extract, 3% astragalosides 25 mg
Holy basil (Ocimum tenuiflorum) leaf extract, 10% ursolic acids 50 mg
Ginseng (Panax ginseng) root extract, 20% ginsenosides 50 mg
Siberian ginseng (Eleutherococcus senticosus) root extract, 0.8% eleutherosides 5 mg
Licorice (Glycyrrhiza glabra) root extract, 10% glycyrrhizin 50 mg
Ashwagandha (Withania somnifera) root extract, 3.5% withanolides 50 mg
Contains no: Preservatives, artificial flavour or colour, yeast, soy, wheat, gluten, dairy, sugar, or starch.
Adrenal SAP contains 90 capsules per bottle.
Adults: 1 capsule two or three times daily. If you are taking other medications, take this product a few hours before or after them. Take with food.
WARNING: Adrenal SAP contains licorice (Glycirrhiza glabra), therefore patients with hypertension should instead use our Adrenal SAP Licorice-Free.
WARNING: If you are pregnant or breast-feeding, consult your health-care practitioner before taking this product.
Adrenal SAP provides nutritive and botanical support for adrenal function to improve energy levels, mental and physical performance, memory, mood, and immune function, as well as to increase the ability to withstand the effects of acute and chronic stress.
The botanicals in Adrenal SAP are ethanol-extracted for standardized isolation of active constituents. Adrenal SAP is supplied in a vegetable capsule for easy digestion.
Purity, Cleanliness, And Stability
Third-party testing is performed on the finished product to ensure Adrenal SAP is free of heavy metals, pesticides, volatile organics, and other impurities.
THE ADRENAL GLAND AND ITS ROLE IN THE BODY
The adrenal glands produce hormones involved in mediating the stress response (epinephrine, norepinephrine, and cortisol), immunity (cortisol), reproduction (including estrogen and testosterone), and blood pressure control (aldosterone). They are a key component of the hypothalamic-pituitary-adrenal (HPA) axis, a complex hormone feedback system between the brain and the adrenal glands that controls the stress response and regulates many body processes including digestion, the immune system, mood and emotions, sexuality, and energy storage and expenditure. The adrenal glands are also involved in the sympatho-adrenal axis, secreting acetylcholine in response to acute stressors to initiate the sympathetic “fight or flight response”.
ADAPTOGENIC HERBS INCREASE THE BODY’S ABILITY TO WITHSTAND ACUTE AND CHRONIC STRESS
An adaptogen is defined as a substance that increases bodily resistance to noxious agents or factors, has a normalizing influence on a pathological state, and increases the ability of an organism to adapt to and avoid damage from environmental factors. The beneficial effects of multidose administration of adaptogens are mainly associated with their effects on the HPA axis via balancing the releases of adrenaline, corticosteroids, and nitric oxide. Conversely, a single dose can mediate the sympatho-adrenal system, providing a rapid response to control the acute reaction to a stressor by dampening the spike in catecholamines, neuropeptides, ATP, nitric oxide, and eicosanoids.
Dysfunction of the HPA axis has been shown to produce clinical symptoms of profound fatigue, unrefreshing sleep, postexertional malaise, headaches, and impaired memory and concentration. A study demonstrated that chronic unpredictable stress (CUS) results in significant depletion of dopamine (DA), noradrenaline (NA), and 5-hydroxytryptophan (5‑HTP) in the hippocampus, in contrast to the sharp increase of these monoamines that occurs when subjected to an acute stressor. The paradoxical decrease in monoamine level in CUS can partly be explained on the basis of increased stress sensitization and their preferential and higher utilization during severe stressful conditions, and supports the theory that long-term stress causes eventual “burnout” of the adrenal gland.
BOTANICAL AND NUTRITIONAL SUPPORT FOR ADRENAL FUNCTION
Siberian ginseng (Eleutherococcus senticosus)
Eleutherococcus has historically been used as a tonic during periods of recovery from surgery and convalescence, and recent research has demonstrated that it increases aerobic metabolism of tissues to facilitate tissue repair. A study of 50 volunteers of both sexes was conducted to examine the effects of an Eleutherococcus extract on immune function and physical fitness. After 30 days of supplementation, researchers documented an increased rate of blastic transformation of lymphocytes, greater maximal oxygen uptake (VO2 max, an indicator of cardiorespiratory endurance), and reduced serum total cholesterol, LDL cholesterol, and triglyceride levels. Even a single dose of this herb results in increased mental performance and physical working capacity, without any of the side effects commonly associated with pharmacological stimulants including addiction, tolerance, abuse potential, disordered sleep, and rebound hypersomnolence.
Panax ginseng (Panax quinquefolium)
Panax species have had widespread use as a general tonic in Southern Asia for more than 5000 years, and are believed to promote health and longevity. Recent research shows that the ginsenosides in this herb are effective in normalizing the negative effects seen with chronic stress in mice: elevated plasma cortisol, increased levels of the proinflammatory cytokines IL2 and IL6, and depletion of noradrenaline, dopamine, and 5-hydroxytryptophan in the hippocampus.
Astragalus (Astragalus membranaceous)
Astragalus is a well-known herb in traditional Chinese medicine, and the saponins from this plant demonstrate significant lymphocyte proliferation and immunostimulatory activities. In a study on diabetic mice, the polysaccharides were shown to enhance the adaptive capacity of the hepatic endoplasmic reticulum, improving insulin sensitivity, and lowering blood glucose.
Ashwaghanda (Withania somnifera)
Ashwanghanda is an adaptogen that has been used in Ayurvedic practice for more than 2500 years. One of the main detrimental effects of chronic stress is immunosuppression. Withania administered orally to chronically stressed mice significantly reversed T-cell depletion and increased the expression of Th1 cytokines. In a rat model of long-term stress, an extract of this herb attenuated symptoms of glucose intolerance, gastric ulcerations, male sexual dysfunction, cognitive deficits, immunosuppression, and mental depression that were seen in control animals.
Holy Basil (Ocimum sanctum)
Holy basil is another important herb in Ayurvedic medicine, and research has shown that it possesses antioxidant, antimicrobial, anti-inflammatory, anthelmintic and radioprotective activities. It has also been shown to lower serum cortisol concentrations and diminish the negative effects of noise stress in a rat model.
Licorice (Glycyrrhiza glabra)
Licorice has been valued for its antimicrobial, anti-inflammatory, lipid-lowering, and antiulcerogenic effects. Seven-day supplementation at a dose of 150 mg/kg in mice was shown to enhance memory and learning capacity and significantly reverse pharmaceutically induced amnesia. This herb has also demonstrated antidepressant effects in mice, comparable to treatment with imipramine (15 mg/kg i.p.) and fluoxetine (20 mg/kg i.p.) via an increase in norepinephrine and dopamine. In addition, Glycirrhiza acts on the adrenal-pituitary-kidney axis to stimulate the release of renin and raise blood pressure.
Schizandra (Schizandra chinensis)
Schizandra is an important herb in traditional Chinese medicine, and has been used as a kidney tonifier to relieve mental strain. In a double-blind, placebo-controlled study of athletes, an extract of schizandra supplemented prior to heavy physical exercise significantly increased performance, and prevented the rise in salivary nitric oxide and cortisol that was observed in the placebo group. This herb has also been shown to be hepatoprotective in mice via enhancement of mitochondrial glutathione status and induction of heat shock proteins which protects against TNF-α-induced apoptosis of liver cells.
Trace Minerals: Magnesium and Zinc
Magnesium is an especially important cofactor in energy production, and has important roles in pH balance and body temperature homeostasis. Supplementation of this mineral in pigs improves ability to handle long-term stress.
Zinc is highly concentrated in the adrenal glands and has structural, enzymatic and regulatory actions. It is required for adrenal hormone production and is depleted during periods of stress.
Vitamin B5, known as the “antistress vitamin,” plays a role in the production of adrenal gland hormones and is required for their proper functioning.
Vitamin B6 is involved in more bodily functions than almost any other single nutrient. It is required for normal nervous system function, in the synthesis of RNA and DNA, and aids in maintaining sodium and potassium balance.
Vitamin C (Ascorbic Acid)
Vitamin C is highly concentrated in the adrenal gland, where it functions as an antioxidant. It is released in response to adrenocorticotropic hormone (ACTH), which is then followed by a decrease in adrenal cholesterol levels, suggesting the role of ascorbate in steroidogenesis. It has been elucidated that vitamin C acts as an auxiliary electron donor in the aldosterone formation system. In a swine model, vitamin C supplementation improved coping ability in response to chronic stress.
Consult a health care practitioner prior to use if you have an auto-immune disorder, have any type of acute infection or are taking antidepressant medications, blood thinners, digoxin, or beta-blockers such as taliniol. Consult a health care practitioner if symptoms persist or worsen. Consult a health care practitioner prior to use if you have a liver disorder. Do not use if you are taking thiazide diuretics, cardiac glycosides, corticosteroids, stimulant laxatives or other medications which may aggravate electrolyte imbalance. Do not use if you have hypokalemia, or kidney or cardiovascular disorder. For adult use only. Do not take if you are pregnant or breastfeeding. Do not use if you are diabetic. Consumption with alcohol, other drugs or natural health products with sedative properties is not recommended. Do not use if you have high blood pressure. Some people may experience insomnia, anxiety, heartburn, skin allergy, constipation or headaches, in which case, discontinue use.
- Magnesium Stearate
- Purified water
- Silicon dioxide
- Astragalus (Astragalus membranaceus) : 25 mg (8:1)
- Siberian ginseng (Eleutherococcus senticosus) : 5 mg
- Licorice (Glycyrrhiza glabra) : 50 mg
- Magnesium : 10 mg
- Holy basil (Ocimum tenuiflorum) : 50 mg (8:1)
- Ginseng (Panax ginseng) : 50 mg
- Vitamin B5 (Pantothenic acid) : 50 mg
- Schisandra (Schisandra chinensis) : 25 mg
- Vitamin B6 : 25 mg
- Vitamin C : 250 mg
- Vitamin C : 250 mg
- Ashwagandha (Withania somnifera) : 50 mg
- Zinc : 5 mg